从石杉科植物千层塔中分得两个新生物碱:石杉碱甲和石杉碱乙,经光谱测定和化学降解阐明它们的结构分别如1和2所示.它们都具有很强的抑制胆碱酯酶活性和提高学习、记忆效率的功能,其中石杉碱甲经临床试验证明对重症肌无力、老年性健忘症和老年性痴呆症有一定疗效. Two new alkaloids, huperzine A and huperzine B, were separated from the pestal column of the genus Pinaceae and their structures were elucidated spectroscopically and chemically, respectively, as shown by 1 and 2. They all have very strong Of the inhibition of cholinesterase activity and improve the learning and memory efficiency of the function, which Huperzine A clinical trial proved to have a certain effect on myasthenia gravis, senile amnesia and Alzheimer’s disease.