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本文报道使用均相配体交换法标记~(99m)锝-特丁基异腈(~(99m)Tc-TBI)的方法和步骤。该法标记方便,产额和放射化学纯度均大于90％,便于临床推广和使用。~(99m)Tc-TBI在大鼠血中清除较快,T_(1/2)α为3.7min,T_(1/2)β为63min,给药后1和2h的心/血比分别为62.2和48.7,心/肺比为3.7和4.0,心/肝比为0.85和0.81,给药后1、2和4h时每克小鼠心肌的百分吸收值分别为11.1±2.6％13.1±2.1％和12.8±1.5％。可见,~(99m)Tc-TBI是一种新型的、有希望的心肌显象剂。
This paper reports the method and procedure for the labeling of ~ (99m) technetium-tert-butylisocyanide (~ (99m) Tc-TBI) using a homogeneous ligand exchange method. The method is easy to mark, the output and radiochemical purity are greater than 90%, for clinical promotion and use. ~ (99m) Tc-TBI was cleared rapidly in rat blood. The T 1/2 (1/2) α was 3.7 min and the T 1/2 (1/2) β was 63 min. The heart / blood ratios at 1 and 2 h after administration were 62.2, and 48.7, heart / lung ratios were 3.7 and 4.0, and heart / liver ratios were 0.85 and 0.81, respectively, at 1, 2 and 4 h after administration of 11.1 ± 2.6% and 13.1 ± 2.1 % And 12.8 ± 1.5%. Can be seen, ~ (99m) Tc-TBI is a new, promising myocardial imaging agent.