PTEN是迄今发现的第一个具有双重特异性磷酸酶活性的肿瘤抑制基因,在细胞的生长发育、凋亡、迁移、信号传递等方面起着重要的调控作用,虽然已经证实PTEN基因的表达水平与多数消化系统肿瘤的发生、发展及预后存在相关性,但其精确作用点、作用机制以及它在消化系统肿瘤发生中的重要性等,均有待于进一步阐述。现对国内外PTEN基因在消化系统肿瘤中的研究进展作一综述。 PTEN is the first tumor suppressor gene discovered to date with dual specific phosphatase activity and plays an important regulatory role in cell growth and development, apoptosis, migration and signal transduction. Although PTEN gene expression level has been confirmed Which is related to the occurrence, development and prognosis of most digestive system tumors. However, its exact point of action, its mechanism of action and its importance in the carcinogenesis of digestive system need to be further elucidated. The research progress of PTEN gene in digestive system tumors at home and abroad are reviewed.