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目的:探讨C-反应蛋白(CRP)在糖尿病肾病(DN)不同阶段的变化及其DN发生发展的关系。方法:用免疫比浊法测定40例正常人群及128例2型糖尿病患者的血清CRP水平,同时测定血清尿素氮(BUN)、血肌酐(SGr)、24h尿白蛋白排除率(UAER),并根据24h尿蛋白排除率将2型糖尿病患者分为3组;正常尿白蛋白组(DN1组);微量白蛋白尿组(DN2组);临床白蛋白组(DN3组)。40例健康人群作为对照组。结果:与对照组比较,DN1组、DN2组、DN3组CRP升高,差异均有显著性(分别P<0.05,P<0.01,P<0.01);DN2、DN3组与DN1组比较,CRP升高,差异具有极显著性(均为P<0.01);DN3组、DN2组比较,CRP明显升高,差异具有极显著性(P<0.01)。而BUN及SGr,与对照组比较,仅DN3组升高,差异具有显著性(<0.01)。结论:CRP水平随着糖尿病肾病的进展及白蛋白尿排泄率的增高而逐渐增高,对糖尿病肾病发生、发展的早期预测具有重要意义。
Objective: To investigate the relationship between the changes of C-reactive protein (CRP) in different stages of diabetic nephropathy (DN) and the occurrence and development of DN. Methods: Serum CRP level was measured by immunoturbidimetry in 40 normal subjects and 128 patients with type 2 diabetes mellitus. Serum urea nitrogen (BUN), serum creatinine (SGr) and urinary albuminuria (UAER) were measured 24h Patients with type 2 diabetes were divided into 3 groups according to the urinary protein excretion rate of 24 hours; normal urinary albumin group (DN1 group); microalbuminuria group (DN2 group); clinical albumin group (DN3 group). 40 healthy people as control group. Results: Compared with the control group, CRP in DN1, DN2 and DN3 groups were significantly increased (P <0.05, P <0.01, P <0.01, respectively) (P <0.01). CRP was significantly increased in DN3 group and DN2 group, the difference was highly significant (P <0.01). The BUN and SGr, compared with the control group, only DN3 group increased, the difference was significant (<0.01). CONCLUSION: The level of CRP gradually increases with the progress of diabetic nephropathy and the increase of albuminuria excretion rate. It is of great significance for the early prediction of occurrence and development of diabetic nephropathy.