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目的:探讨红细胞体积分布宽度(RDW)异常的原因、分级及其临床意义。方法:用法国产的ABX-120型全自动血球记数仪测定388例各种疾病的RDW、MCV、Hb,同期测定100例健康儿童的RDW、MCV、Hb;根据RDW值大小分4组,分别是RDW降低组、RDW正常组、轻度升高组、重度升高组。结果:100例健康儿童RDW降低组2例,正常组98例;388例病例中RDW降低组(<12.0%)2例,RDW正常组(12.0%～14.9%)22例,轻度升高组(15.0%～27.4%)315例,重度升高组(≥27.5%)49例;各种疾病观察组RDW均高于健康对照组(P<0.001)。结论:轻度地中海贫血、缺铁性贫血、炎症及新生儿RDW均可轻度升高;地中海贫血RDW与贫血程度呈负相关;急性溶血性贫血RDW与贫血程度无明显相关。
Objective: To investigate the reason, classification and clinical significance of abnormal distribution width of erythrocytes (RDW). Methods: RDW, MCV and Hb of 388 cases of various diseases were measured by ABX-120 automated hemocytometer in France. RDW, MCV and Hb were measured in 100 healthy children in the same period. According to the RDW value, they were divided into 4 groups Is RDW reduction group, RDW normal group, mild increase group, severe increase group. Results: Among 100 healthy children, RDW reduced group (n = 2) and normal group (n = 98). Among 388 cases, RDW reduced group (<12.0%), RDW normal group (12.0% ~ 14.9% (15.0% ~ 27.4%) in 315 cases and severe increase group (≥27.5%) in 49 cases. The RDW of various disease observation groups were higher than that of healthy control group (P <0.001). CONCLUSIONS: Mild thalassemia, iron-deficiency anemia, inflammation and neonatal RDW may be mildly elevated; thalassemia RDW is negatively correlated with anemia; acute hemolytic anemia RDW is not significantly associated with anemia.