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为观察吸烟者肺泡接触段和小气道形态的计量特点，以探讨吸烟者肺泡接触段破坏的发生与小气道形态异常的关系。应用图象分析技术对３６例吸烟者肺泡接触段和小气道形态进行计量学分析。分为：无肺气肿组（ＮＥ），小叶中央型肺气肿组（ＣＬＥ）和全小叶型肺气肿组（ＰＬＥ）。肺泡接触段参数中，ＣＬＥ的相邻两个正常肺泡接触段之间的距离（距离）和异常肺泡接触段百分数（异常接触数％）显著高于ＮＥ（Ｐ＜０．０５和Ｐ＜０．０１），三组间的正常肺泡接触段参数无明显区别；小气道形态参数中，ＣＬＥ的小气道管壁面积（ＷＡ）和扭曲系数（ＤＩ）明显不同于ＮＥ（均Ｐ＜０．０５）；ＰＬＥ和ＮＥ间这些参数均无明显区别；距离和异常接触数的百分率分别与ＷＡ和ＤＩ显著相关，但这种关系仅见于ＣＬＥ。说明吸烟者肺泡接触段的破坏与小气道形态异常有密切关系，提示不同类型的肺气肿ＣＬＥ和ＰＬＥ可能各自有完全不同的发病机制。
In order to observe the measurement characteristics of alveolar contact section and small airway morphology in smokers, the relationship between the destruction of alveolar contact section and the abnormality of small airway in smokers was explored. The image analysis technique was used to measure the alveolar contact section and the small airway morphology in 36 smokers. Divided into: no emphysema group (NE), lobular central emphysema group (CLE) and total lobular emphysema group (PLE). In the parameters of alveolar contact, the distance (distance) and the percentage of abnormal alveolar contact (% of abnormal contact) between two adjacent alveolar contacts of CLE were significantly higher than that of NE (P <0.05 and P <0). 01). There was no significant difference in the parameters of normal alveolar contact between the three groups. Small airway wall area (WA) and torsional coefficient (DI) of small airway morphology parameters were significantly different from those of NE (all P <0.05) ; There was no significant difference between PLE and NE; the percentage of distance and abnormal contact were significantly correlated with WA and DI respectively, but the relationship was only seen in CLE. This shows that the destruction of alveolar contact section of smokers is closely related to the abnormality of small airway morphology, suggesting that different types of emphysema CLE and PLE may have completely different pathogenesis.