论文部分内容阅读
目的观察氯吡格雷(clopidogrel)应用于非ST段抬高心肌梗死患者急诊介入治疗的作用。方法选择诊断为非ST段抬高心肌梗死患者112例,随机分为对照组和氯吡格雷组,每组各56例,均实行相同的标准治疗。病例均急诊行冠脉造影及冠脉介入治疗(PCI)。氯吡格雷组除标准治疗外,入院即刻给予氯吡格雷,对照组给予噻氯匹啶。2组均随访半年。结果PCI术后氯吡格雷组患者的TIMI 3级血流获得数为91.1%,较对照组(87.5%)高,2组间差异无统计学意义(P>0.05)。2组在心功能分级、威胁生命出血方面亦无统计学差异(P>0.05)。氯吡格雷组轻度出血明显少于对照组(P<0.05),氯吡格雷组血小板降低程度、白细胞总数均明显低于对照组(P<0.05)。半年的随访中,氯吡格雷组联合终点与对照组比较差异有统计学意义(P<0.05)。结论氯吡格雷对非ST段抬高心肌梗死患者急诊介入治疗有良好的效果,能降低急诊介入治疗的心血管事件风险。
Objective To investigate the effect of clopidogrel in emergency interventional therapy in patients with non-ST-elevation myocardial infarction. METHODS: One hundred and twelve patients with non-ST-segment elevation myocardial infarction were selected and randomly divided into control group and clopidogrel group, with 56 patients in each group. All patients underwent the same standard treatment. All patients underwent emergency coronary angiography and coronary intervention (PCI). Clopidogrel group in addition to standard treatment, admission to clopidogrel immediately, the control group was given ticlopidine. Two groups were followed up for six months. Results The TIMI grade 3 blood flow in patients with clopidogrel after PCI was 91.1%, which was higher than that in the control group (87.5%). There was no significant difference between the two groups (P> 0.05). There was no significant difference between the two groups in the classification of cardiac function and life-threatening hemorrhage (P> 0.05). The slight hemorrhage in clopidogrel group was significantly less than that in control group (P <0.05). The degree of thrombocytopenia and the total number of white blood cells in clopidogrel group were significantly lower than those in control group (P <0.05). In the six-month follow-up, the difference between the combined endpoint of clopidogrel group and the control group was statistically significant (P <0.05). Conclusion Clopidogrel has a good effect on emergency interventional therapy in patients with non-ST-elevation myocardial infarction, and can reduce the risk of cardiovascular events in emergency interventional therapy.