题解1.氢甲苯咪酮是新型正性肌力作用的药物,其强心作用并非通过兴奋β受体,而可能与心脏磷酸二酯酶Ⅲ受抑制有关,使心肌细胞内环磷腺苷(cAMP)浓度增高,促进细胞外钙离子(Ca~(2+))内流,肌浆网主动摄取Ca~(2+)及激活磷酸化酶而使糖原分解增加,三磷酸腺苷(ATP)生成增多使心肌收缩力增强。此外,高浓度时尚能抑制钠离子(Na~+)-钾离子(K~+)- Hydrochlorobenone is a new type of positive inotropic drugs, its cardiac effect is not through the excitement β receptor, and may be related to the inhibition of cardiac phosphodiesterase Ⅲ, so that intracellular cyclic adenosine monophosphate ( cAMP), promote the influx of extracellular calcium (Ca2 +), sarcoplasmic reticulum take the initiative to take Ca2 + and activate phosphorylase, which can increase glycogen and increase the production of adenosine triphosphate (ATP) So that myocardial contractility increased. In addition, high concentrations of fashion can inhibit the sodium (Na ~ +) - potassium (K ~ +) -