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10只大鼠经口给氯喹280mg/kg/d×3后,9只中毒死亡.孕鼠于D_8起给氯喹70mg/kg/d×3,其总剂量为临床总剂量的7倍时,有轻度胚胎毒性,表现为活胎率下降及胎仔平均体重减轻。氯喹剂量增至140mg/kg/d×3时,胎仔骨骼畸形发生率为29％(16/55),较对照组的明显为高,P<0.01;若与乙胺嘧啶7mg/kg/d×3(总剂量相当临床总剂量的10.5倍)组相比,后者的胎仔骨骼畸变率69.2％(27/39)与侧脑室扩大率29％(9/31)又明显高于氯喹140mg/kg/d×3(总剂量为临床总剂量的14倍)组。此外,孕鼠服氯喹与乙胺嘧啶后,尚有阴道与眼眶出血等中毒症状。
Ten rats were poisoned by chloroquine 280 mg / kg / d × 3 after oral administration, and 9 rats were poisoned.Under the administration of chloroquine 70 mg / kg / d × 3 from D8 to the total dose of 7 times of the total clinical dose, Mild embryotoxicity, manifested as a decrease in live birth rate and average weight loss of the litter. When the dose of chloroquine was increased to 140mg / kg / d × 3, the incidence of fetal skeletal deformity was 29% (16/55), which was significantly higher than that of the control group (P <0.01). When combined with pyrimethamine 7mg / kg / d (27/39) and 29% (9/31) of lateral ventricles were significantly higher than those of chloroquine 140mg / kg / d x 3 (total dose 14 times the total clinical dose) group. In addition, pregnant rats serving chloroquine and pyrimethamine, there are vaginal and orbital bleeding and other symptoms of poisoning.