本论文研究了新月弯孢霉KA-91对甘草次酸的微生物转化。该菌株在28℃、180 r/min条件下振荡培养24 h,加入终浓度为0.04%的甘草次酸乙醇溶液。56 h后,停止转化。通过TCL、HPLC、MS1、H NMR和13C NMR分析,转化产物鉴定为7β羟基甘草次酸,转化率为41.1%;该研究丰富了新月弯孢霉作用底物范围,为7β-羟基甘草次酸的合成提供了一条新途径。 In this paper, the microbial transformation of Curvularia lunata KA-91 to glycyrrhetinic acid was studied. The strain was cultured under shaking at 180 r / min for 24 h at 28 ° C. A solution of glycyrrhetinic acid in a final concentration of 0.04% was added. After 56 h, stop conversion. The conversion product was identified as 7β-hydroxyglycyrrhetinic acid by TCL, HPLC, MS1, H NMR and 13C NMR. The conversion rate was 41.1%. This study enriched the substrate range of Curvularia lunata as 7β-hydroxy licorice Acid synthesis provides a new way.