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本文研究了7名正常人和10名患有支气管哮喘病人的血清茶碱浓度(C_p)和唾液茶碱浓度(C_s)相关性。其C_s/C_p平均比值分别为0.52±0.01和0.51±0.01,其相关系数分别为0.9956和0.9935。实验中还观察到,无论正常人还是病人,C_s/C_p比值不受给药途径和标本采集时间的影响。由C_s和C_p分别求得的药动学参数没有统计学上的差异(p>0.05)。研究表明:唾液标本可以作为茶碱日常监测的样品。
This article studied the correlation between serum cardiophyllin concentration (C_p) and saliva theophylline concentration (C_s) in seven normal subjects and ten patients with bronchial asthma. The average ratio of C_s / C_p was 0.52 ± 0.01 and 0.51 ± 0.01, the correlation coefficients were 0.9956 and 0.9935 respectively. The experiment also observed that, regardless of normal or patient, C_s / C_p ratio is not affected by the route of administration and specimen collection time. The pharmacokinetic parameters obtained by C_s and C_p respectively were not statistically different (p> 0.05). Research shows that saliva samples can be used as theophylline routine monitoring samples.