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巨噬细胞的铁代谢与结核分枝杆菌的生长繁殖有密切的关系。结核分枝杆菌感染宿主后,主要在宿主巨噬细胞内生长繁殖,巨噬细胞为其生长提供所需要的铁元素,而未被机体免疫系统清除的结核分枝杆菌必须依靠巨噬细胞提供铁元素才能维持其活性和生存。巨噬细胞内转铁蛋白受体1(TfR1)不仅维持巨噬细胞内铁元素的动态平衡,影响胞内结核分枝杆菌生存,而且诱导巨噬细胞自身凋亡,最终杀伤结核分枝杆菌。近年来,有研究表明铁元素与结核分枝杆菌耐药相关。研究铁元素在结核病的发生、发展机制以及结核病耐药机制中的作用,对进一步明确结核病的发病机制,开创治疗结核病的新方法有重要意义。
The iron metabolism of macrophages is closely related to the growth and reproduction of Mycobacterium tuberculosis. Mycobacterium tuberculosis infection host, the main growth and reproduction in host macrophages, macrophages for its growth to provide the required iron, but not by the body’s immune system to eliminate Mycobacterium tuberculosis must rely on macrophages to provide iron Elements in order to maintain their activity and survival. Macrophage transferrin receptor 1 (TfR1) not only maintain the dynamic balance of iron in macrophages, affect the survival of intracellular M. tuberculosis, but also induce the apoptosis of macrophages and ultimately kill M. tuberculosis. In recent years, studies have shown that iron is associated with resistance to Mycobacterium tuberculosis. Studying the role of iron in the pathogenesis of tuberculosis, its mechanism of development and drug resistance in tuberculosis plays an important role in further clarifying the pathogenesis of tuberculosis and creating a new method of treating tuberculosis.