论文部分内容阅读
目的:通过动物体内抑瘤实验和血清药理学实验比较,探讨体内抑瘤试验与血清药理学实验的一致性。方法:选择4个体内抗癌试验有效的样品(中药复方制剂)进行体内及血清药理学的试验。其中血清药理学实验采用10%和20%的含药血清进行体外抑瘤试验,用MTT法检测4种样品含药血清对不同肿瘤细胞的细胞增殖的影响。结果:4种样品体内抑瘤实验显示明确的抗肿瘤活性,血清药理学同样显示一定的抗癌活性,且G、H药P<0.01,X、T药P<0.05。结论:体内抑瘤有效的抗肿瘤方剂血清药理学检测均有抗癌活性,与体内试验一致。
OBJECTIVE: To compare the in vivo anti-tumor and serum pharmacology experiments by comparing the anti-tumor and serum pharmacological experiments in animals. Methods: Four in vivo anticancer test samples (Chinese compound preparation) were selected for in vivo and serum pharmacological tests. Serum pharmacology experiments using 10% and 20% serum containing anti-tumor test in vitro, using MTT assay four samples containing serum on the proliferation of different tumor cells. Results: The antitumor activity of the four samples in vivo showed clear anti-tumor activity. Serum pharmacology also showed some anticancer activity. The G, H drugs, P <0.01, X, T drugs, P <0.05. Conclusion: In vivo anti-tumor anti-tumor prescription anti-cancer pharmacological tests have anti-cancer activity, in line with in vivo experiments.