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目的分析子宫动脉化疗栓塞治疗难治性妊娠滋养细胞肿瘤及肿瘤出血的临床疗效。方法 90例难治性妊娠滋养细胞肿瘤患者为研究对象,随机分为实验组与对照组,各45例。对照组采用常规方案进行治疗,实验组采用子宫动脉化疗栓塞治疗。比较两组患者的治疗效果、术中出血量、出血停止时间、治疗后1年复发情况。结果实验组患者总有效率93.33%高于对照组的60.00%,差异具有统计学意义(χ~2=13.975,P<0.05)。实验组患者术中出血量(272.45±1.74)ml少于对照组的(368.41±1.87)ml,差异具有统计学意义(t=252.013,P<0.05)。实验组患者出血停止时间(3.00±0.24)d短于对照组的(7.00±1.96)d,差异具有统计学意义(t=13.589,P<0.05)。治疗后1年,实验组复发率0低于对照组的15.56%,差异具有统计学意义(χ~2=7.590,P<0.05)。结论采用子宫动脉化疗栓塞治疗难治性妊娠滋养细胞肿瘤,可有效提升治疗效果,减少出血量,降低后期复发率,可广泛运用。
Objective To analyze the clinical effect of uterine arterial chemoembolization on refractory gestational trophoblastic tumor and tumor hemorrhage. Methods Ninety patients with refractory gestational trophoblastic tumor were randomly divided into experimental group and control group, with 45 cases in each group. The control group was treated with conventional regimen, and the experimental group was treated with uterine artery chemoembolization. The curative effect, the amount of blood loss, the stopping time of bleeding and the relapse of one year after treatment were compared between the two groups. Results The total effective rate of the experimental group was 93.33% higher than that of the control group (60.00%), the difference was statistically significant (χ ~ 2 = 13.975, P <0.05). The amount of blood loss in the experimental group was (272.45 ± 1.74) ml less than that in the control group (368.41 ± 1.87) ml, the difference was statistically significant (t = 252.013, P <0.05). The bleeding time in the experimental group was shorter than that in the control group (3.00 ± 0.24) days, and the difference was statistically significant (t = 13.589, P <0.05). One year after treatment, the recurrence rate in the experimental group was lower than that in the control group (15.56%) (χ ~ 2 = 7.590, P <0.05). Conclusion Uterine arterial chemoembolization in the treatment of refractory gestational trophoblastic tumor can effectively improve the therapeutic effect, reduce the amount of bleeding and reduce the late recurrence rate, which can be widely used.