变应性慢性炎症应答前患者对抗原的早期应答包括即刻反应和迟发相反应（fatphasereaction），后者为抗原接触数小时后的症状再发和介质再释放，作者们曾报道抗原鼻粘膜激发后的组胺释放来源于嗜碱细胞；相继报道迟发相反应中有嗜碱细胞存在，但不排除肥大细胞作为组胺释放来源 Early responses to antigens in patients with a pre-allergic chronic inflammation response include immediate and delayed fatphase reactions, which are symptoms recurrence and media release several hours after antigen exposure, and the authors have reported that antigen nasal mucosal excitation Post-histamine release from basophils; late-phase response has been reported in the presence of basophils, but does not rule out the use of mast cells as a source of histamine release