Vertical total electron content is examined to check whether the Ms7. 1 Yushu earthquake on April 14, 2010, may have caused any anomalous ionospheric changes. The result shows two TEC increases over the epicenter vicinity on April 1 and 5; these anomalies drifted from east to west, the latter across the whole China. The increase on April 5 was probably related to geomagnetic activity, whereas the one on April 1 may possibly be related to the Yushu earthquake.