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喉癌是头颈部的恶性肿瘤 ,癌细胞向周围组织的快速浸润和淋巴结转移是影响患者预后的主要原因。有关 E- CD( E- cadherin)的基因突变及 E- CD蛋白表达与喉癌的相关性已被报道 ,但研究发现 E-CD表达正常的肿瘤也有高转移的倾向。胞内连环素通过与 E- CD结合共同参与细胞间粘附 ,
Laryngeal cancer is a head and neck cancer, cancer cells to the rapid infiltration of surrounding tissues and lymph node metastasis is the main reason affecting the prognosis of patients. E-cadherin (E-cadherin) gene mutations and E-CD protein expression and laryngeal cancer has been reported, but studies have found that E-CD expression of normal tumors also have a high tendency to metastasis. Intracellular catenin participates in intercellular adhesion by binding to E-CD,