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目的探讨运动疗法与基质细胞衍生因子-1(SDF-1α)对促进脑梗死患者下肢运动功能恢复的作用。方法采用随机数字表法将72例脑梗死患者分为脑梗死后非运动组与脑梗后运动组,另选30名健康老人作对照。脑梗死后非运动组患者采取常规治疗;脑梗死后运动组患者在常规治疗的基础上,进行减重步行训练。分别在脑梗死后第1周、第4周、2个月、3个月4个时点检测外周血SDF-1α水平,采用FMA运动量表评估下肢运动功能恢复情况。结果脑梗死运动组患者SDF-1α水平从脑梗死后第4周开始均较脑梗死非运动组高(均P<0.05);脑梗死运动组患者其下肢FMA评分从第4周开始,均明显高于脑梗死非运动组患者(P<0.05)。结论减重步行训练极有可能通过促进SDF-1α的分泌,进而帮助脑梗死后下肢运动功能的恢复。
Objective To investigate the effects of exercise therapy and stromal cell-derived factor-1 (SDF-1α) on the recovery of lower extremity motor function in patients with cerebral infarction. Methods Seventy-two patients with cerebral infarction were divided into non-exercise group and cerebral-infarction group after cerebral infarction by random number table method, and 30 healthy controls were selected as control. After cerebral infarction non-exercise group of patients taking conventional treatment; exercise group after cerebral infarction on the basis of routine treatment, weight-loss walking training. The levels of SDF-1α in peripheral blood were measured at the first week, the fourth week, the second month and the third month respectively after cerebral infarction. The recovery of motor function of the lower limbs was evaluated by FMA scale. Results The levels of SDF-1α in stroke group were significantly higher than those in non-exercise group (all P <0.05) at 4 weeks after cerebral infarction. FMA scores of lower limbs in patients with cerebral infarction were significantly higher than those at 4 weeks Higher than non-exercise group of patients with cerebral infarction (P <0.05). Conclusion Weight-loss walking training is very likely to promote SDF-1α secretion, and then help to restore motor function of lower extremity after cerebral infarction.