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目的探讨检测血清细胞质胸苷激酶(TK1)在直肠癌诊治中的临床价值。方法利用增强化学发光法(ECLA)检测108例直肠癌患者(直肠癌组)血清TK1的含量,同时检测45例直肠良性疾病(良性疾病组)和48名健康人血清(正常对照组)中的TK1含量。结果直肠癌组TK1水平为[2.45(1.27～3.85)pm/L],显著高于良性疾病组的[(1.25(0.76～1.45)pm/L]和正常对照组的[1.16(0.69～1.38)pm/L](P<0.01);良性疾病组和正常对照组之间差异无统计学意义(P>0.05)。结论血清TK1检测在直肠癌诊断方面具有一定的临床应用价值。
Objective To investigate the clinical value of detecting serum cytoplasmic thymidine kinase (TK1) in the diagnosis and treatment of rectal cancer. Methods The levels of TK1 in 108 patients with rectal cancer (rectal cancer) were detected by enhanced chemiluminescence (ECLA) assay. The levels of TK1 in 45 rectal benign diseases (benign diseases) and 48 healthy controls (normal controls) TK1 content. Results The level of TK1 in rectal cancer was significantly higher than that in benign diseases [(1.25 (0.76 ~ 1.45) pm / L] and [1.16 (0.69 ~ 1.38) (P <0.01). There was no significant difference between the benign disease group and the normal control group (P> 0.05) .Conclusion The serum TK1 test has certain clinical value in the diagnosis of rectal cancer.