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目的探讨Survivin、P53、Rb蛋白在高发区食管癌中的表达及其与临床病理的关系。方法用免疫组化法对85例高发区食管癌组织及癌旁正常组织中Survivin和P53、Rb基因表达进行检测,分析Survivin、P53、Rb表达与食管癌临床病理的关系。结果Survivin与P53蛋白在食管癌组织中的表达明显高于癌旁正常组织(P<0.01)。Survivin与患者的TNM分期和淋巴结转移与否有关(P<0.05),Survivin与P53表达显著相关(P<0.05)而与Rb表达无明显相关(P>0.05)。结论Survivin蛋白的表达与食管癌的临床分期和淋巴结转移有关,Survivin与P53蛋白可作为食管癌检测的一个分子生物学指标,Rb可做为食管癌恶性程度以及预后的一个指标。
Objective To investigate the expression of Survivin, P53 and Rb protein in esophageal cancer and its relationship with clinicopathological features in high incidence area. Methods The expressions of Survivin, P53 and Rb in 85 cases of esophageal cancer tissues and adjacent normal tissues were detected by immunohistochemistry. The relationship between Survivin, P53 and Rb expression and clinicopathological features of esophageal carcinoma was analyzed. Results The expression of Survivin and P53 protein in esophageal cancer tissues was significantly higher than that in adjacent normal tissues (P <0.01). Survivin was correlated with TNM stage and lymph node metastasis (P <0.05). Survivin was significantly correlated with P53 expression (P <0.05), but not with Rb expression (P> 0.05). Conclusion The expression of Survivin protein is correlated with the clinical stages and lymph node metastasis of esophageal cancer. Survivin and P53 protein may be used as molecular biological markers for the detection of esophageal cancer. Rb may be used as an indicator of malignancy and prognosis of esophageal cancer.