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Objective To investigate the changes of the concentration of interkeukine β 1(IL-1β) and Interleukine 6(IL-6) in the serum of the people who live in the different altitude, and try to find the relation between the cytokines (CK) and the hypoxia adaptation and some diseases caused by hypoxia. Methods Using enzyme linked immunoabsorbent assay (ELISA) to detect the level of the concentration of IL-1β and IL-6 in the serum. Results The concentration of IL-1β showed significant increase in values (P