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目的:探讨乌司他丁治疗胆道感染性休克的META分析。方法:对中国期刊全文数据库、维普中文科技期刊、万方数据库、SCI、EMBASE、Pubmed等进行文献检索,制定相关纳入标准,将关于乌司他丁治疗胆道感染性休克的相关文献进行筛选,并用Rev Man 5.1软件进行META分析。结果:按照纳入标准,共纳入5篇相关乌司他丁治疗胆道感染性休克的相关文献,META分析结果表明:5篇文献结果均为利用乌司他丁治疗的治疗组与非乌斯他丁治疗的对照组比较:心率(HR)在治疗后的6 h内下降幅度治疗组高于对照组,差异具有统计学意义(P<0.01)。1篇治疗组血浆丙二醛(MDA)下降程度大于对照组,并且2篇超氧化物歧化酶(SOD)水平升高程度大于对照组。结论:乌司他丁治疗胆道感染性休克时可以有效的改善MDA、SOD、HR以及MAP的水平,对胆道休克感染的血流动力学和氧自由基的异变进行有效干预。
Objective: To investigate the effect of ulinastatin on biliary septic shock by META. Methods: The Chinese Journal Full-text Database, VIP Chinese Science and Technology Periodicals, Wanfang Database, SCI, EMBASE, Pubmed and other literature retrieval, to develop relevant inclusion criteria, the relevant literature on ulinastatin biliary septic shock screening, and use RevMan 5.1 software for META analysis. Results: According to the inclusion criteria, five articles related to ulinastatin in the treatment of biliary septic shock were included in the literature. The results of META analysis showed that all the five articles were treated with ulinastatin and non-uestatin Compared with the control group, the decrease of heart rate (HR) within 6 h after treatment was higher in the treatment group than in the control group, with statistical significance (P <0.01). The plasma malondialdehyde (MDA) in one treatment group decreased more than that in the control group, and the level of two superoxide dismutase (SOD) increased more than the control group. Conclusion: Ulinastatin can effectively improve the level of MDA, SOD, HR and MAP in the treatment of biliary septic shock and effectively interfere the hemodynamics and the change of oxygen free radical in patients with biliary shock.