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建立19只犬(37例次)急性心肌梗塞后室性心动过速(VT)模型。心外膜低温标测32例,确定VT起源灶19例(59%)。起源灶心肌供血的小冠状动脉内注射95%乙醇0.3～1.2ml(平均0.5ml)14例,10例(71%)未再诱发。心肌内注射95%乙醇1～3ml者9例(包括血管内注射无效4例),有效6例,总有效率84%。7只正常犬小冠状动脉内注射95%乙醇0.4～1.2ml,观察24小时心电图、CK-MB、血液动力学和病理学改变。本文证实冠状动脉内注射乙醇消除VT起源灶效果肯定,有明确的实用价值,但应尽量减小心肌损伤的范围。
Ninety-seven dogs (37 cases) with ventricular tachycardia (VT) after acute myocardial infarction were established. Epicardial low temperature mapping in 32 cases, 19 cases of VT origin (19%) were identified. Fourteen cases of 95% ethanol 0.3 ~ 1.2ml (0.5ml on average) were injected into the small coronary artery of the originating heart and 10 cases (71%) were not induced. Myocardial injection of 95% ethanol 1 ~ 3ml in 9 cases (including intravascular injection in 4 cases), effective in 6 cases, the total efficiency of 84%. Seven normal dogs were injected intraperitoneally with 95% ethanol 0.4 ~ 1.2ml. The electrocardiogram, CK-MB, hemodynamic and pathological changes were observed 24 hours later. This article confirms the coronary artery injection of ethanol to eliminate VT origin Focal affirmative, have clear practical value, but should minimize the scope of myocardial injury.