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目的探讨急性缺血性脑卒中的SSS-TOAST分型中的各个亚型与高敏C反应蛋白(hs-CRP)和糖化血红蛋白(HbA1C)的相关性。方法选取急性缺血性脑卒中患者170例,根据SSS-TOAST分型标准分为大动脉粥样硬化性脑卒中(Large artery atherosclerosis,LAA)、心源性脑栓塞(Cardio-aortic embolism,CE)、小动脉闭塞性脑卒中(Small artery occlusion,SAO)、其他确定病因引起的缺血性脑卒中(Stroke of otherdemonstrated etiology,SOE)和原因不明的缺血性脑卒中(Stroke of undemonstrated etiology,SUE)5个亚型,同时测定各个亚型患者血液中hs-CRP和HbA1C的浓度。结果大动脉粥样硬化性脑卒中(LAA)和原因不明的缺血性脑卒中(SUE)患者血中的hs-CRP的浓度高于其余3组(P<0.05),且LAA又高于SOE(P<0.05);小动脉闭塞性脑卒中(SAO)患者血中的HbA1C的浓度高于其余4组(P<0.05)。结论 hs-CRP的浓度可能与动脉粥样硬化斑块的不稳定性相关,HbA1C的浓度可能与小血管病变相关,测定hs-CRP和HbA1C的浓度有助于SSS-TOAST分型的研究。
Objective To investigate the correlation between the subtypes of SSS-TOAST typing and hs-CRP and HbA1C in patients with acute ischemic stroke. Methods One hundred and seventy patients with acute ischemic stroke were enrolled in this study. According to SSS-TOAST classification criteria, they were divided into two groups: large artery atherosclerosis (LAA), cardio-aortic embolism (CE) Small artery occlusion (SAO), other Stroke of other confirmed etiology (SOE) and Stroke of undetected etiology (SUE) 5 A subtype, at the same time determination of each subtype of blood hs-CRP and HbA1C concentration. Results The concentration of hs-CRP in blood of patients with atherosclerotic stroke (LAA) and unexplained ischemic stroke (SUE) was higher than that of the other three groups (P <0.05), and LAA was higher than that of SOE P <0.05). The concentration of HbA1C in the blood of patients with arteriovenous occlusive stroke (SAO) was higher than the other 4 groups (P <0.05). Conclusion The concentration of hs-CRP may be related to the instability of atherosclerotic plaque. The concentration of HbA1C may be related to small vessel disease. The determination of the concentrations of hs-CRP and HbA1C may be helpful for SSS-TOAST classification.