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目的:探讨共刺激分子4-1BBL(CD137L)在胶质瘤组织中的表达及其临床意义。方法:免疫组化方法检测4-1BBL在82例脑胶质瘤组织中的表达,并分析其与病理分级、患者年龄、性别及生存时间的关系。结果:正常3例脑组织标本未见4-1BBL表达。82例胶质瘤标本31例4-1BBL阳性,阳性表达率为37.8%。统计学提示组织标本中4-1BBL表达与病理级别无明显相关性,与年龄有关(P<0.05),4-1BBL阳性患者生存期更长(P<0.05)。结论:4-1BBL在部分胶质瘤组织中有表达,其表达对判断胶质瘤患者的预后有一定的参考价值。
Objective: To investigate the expression of costimulatory molecule 4-1BBL (CD137L) in glioma tissue and its clinical significance. Methods: Immunohistochemical method was used to detect the expression of 4-1BBL in 82 glioma tissues, and its relationship with pathological grade, age, gender and survival time was analyzed. Results: No normal 4-1BBL expression was found in 3 normal brain tissue samples. Of the 82 glioma specimens, 4 were positive for 4-1BBL, the positive rate was 37.8%. Statistical analysis showed that there was no significant correlation between the expression of 4-1BBL and the pathological grade in the histological specimens (P <0.05). The survival time of 4-1BBL positive patients was longer (P <0.05). Conclusion: 4-1BBL is expressed in some glioma tissues and its expression is of certain value in judging the prognosis of glioma patients.