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目的:探讨染色体8q24两个单核苷酸多态性位点(SNPs)rs6983267和rs1447295,与北京地区前列腺癌(PCa)的相关性。方法:采用病例-对照研究,入选了154例PCa患者和138名正常对照者,检测2个SNPs在病例组和对照组间的等位基因及基因型的分布情况,并分析危险基因型的累积效应。结果:rs6983267有TT、GT及GG 3种基因型,在病例组的分布分别为33.1%、46.4%及20.5%,在对照组的分布分别为32.6%、48.5%及18.9%;rs1447295也有AA、AC及CC 3种基因型,在病例组的分布分别为3.3%、38.2%及58.6%,在对照组的分布分别为1.5%、32.1%及66.4%。2个SNPs的风险等位基因和基因型频率在病例组和对照组间的分布差异无统计学意义,P>0.05。与不具有风险基因型的个体相比,具有1个和同时具有2个风险基因型的个体PCa的发病风险虽然分别提高了1.231和1.571倍,但差异无统计学意义,P>0.05。结论:SNPs rs6983267和rs1447295可能与北京地区PCa的易感性无关。
Objective: To investigate the association of two SNPs rs6983267 and rs1447295 on chromosome 8q24 with PCa in Beijing. METHODS: A case-control study of 154 PCa patients and 138 normal controls was performed. The distribution of alleles and genotypes of two SNPs between the case and control groups was examined and the cumulative risk genotypes were analyzed effect. Results: There were three genotypes of TT, GT and GG in rs6983267, which were 33.1%, 46.4% and 20.5% respectively in the case group and 32.6%, 48.5% and 18.9% in the control group respectively. Rs1447295 also had AA, AC and CC genotypes were 3.3%, 38.2% and 58.6% in the case group and 1.5%, 32.1% and 66.4% in the control group respectively. There were no significant differences in the distribution of risk alleles and genotype frequencies between the two SNPs in case group and control group (P> 0.05). Compared with individuals without risk genotypes, the risk of PCa with one genotype and two genotypes increased by 1.231 and 1.571 times, respectively, but the difference was not statistically significant (P> 0.05). Conclusion: SNPs rs6983267 and rs1447295 may not be related to PCa susceptibility in Beijing.