通过应用环磷酰胺小鼠腹腔注射,观察发现可以影响小鼠生殖激素T、FSH、LH水平,致睾丸形态组织学以及理化特性的改变,引发精子发生以及成熟障碍,造成精子数目减少或质量降低甚至于无精子。说明本实验应用环磷酰胺小鼠腹腔注射制造少精症模型基本成功。 Through the intraperitoneal injection of cyclophosphamide in mice, it was found that it can affect the reproductive hormones T, FSH, LH levels in mice, resulting in histopathological and histochemical changes of testis, triggering spermatogenesis and maturation, resulting in the reduction of sperm count or quality Even without sperm. This experiment shows that the application of cyclophosphamide mice intraperitoneal injection of oligozoospermia model of basic success.