位于染色体22q12上的EWSR1基因是一种混杂融合伙伴,参与大量具有融合基因为特点的肿瘤发生。该研究作者报道了骨血管瘤中发现的新的融合基因--EWSR1-NFATC1。在这类肿瘤中尚未见基因重排的报告。染色体显带分析表明t(11;22)(q23;q12)易位是唯一的改变。荧光原位杂交绘图揭示两个伙伴基因均参与其中。逆转录聚合酶链反应揭示框内 The EWSR1 gene on chromosome 22q12 is a promiscuous fusion partner involved in the oncogenesis of a large number of genes that have a fusion gene. The study authors report the new fusion gene found in hemangiomas - EWR1-NFATC1. There are no reports of gene rearrangements in these tumors. Chromosome banding analysis showed that the t (11; 22) (q23; q12) translocation was the only change. Fluorescence in situ hybridization mapping revealed that both partner genes were involved. RT-PCR revealed in-frame