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哮喘患儿气道炎症形成和发展过程中,细胞因子和炎性介质起着重要的作用,随着大多数炎性介质性质被确定,炎性介质特异性的受体拮抗剂:组胺受体阻断剂、白三烯受体拮抗剂、血栓素受体拮抗剂、血小板激活因子拮抗剂、白细胞介素(IL)受体拮抗剂、抗IgE抗体治疗、神经激肽受体拮抗剂、内皮素受体拮抗剂等也被发现。受体拮抗剂的研究和应用也成为哮喘防治的热点,但如何根据不同的患者选择不同的炎性介质拮抗剂进行有效的哮喘治疗仍需更多、更深入的研究。
Cytokines and inflammatory mediators play an important role in the pathogenesis and progression of airway inflammation in asthmatic children. As most of the inflammatory mediators have been identified, inflammatory mediators specific for histamine receptors Blockers, leukotriene receptor antagonists, thromboxane receptor antagonists, platelet activating factor antagonists, interleukin (IL) receptor antagonists, anti-IgE antibody therapeutics, neurokinin receptor antagonists, endothelium Supramolecular antagonists have also been found. The research and application of receptor antagonists have also become the focus of prevention and treatment of asthma. However, more and more studies are needed on how to treat asthma effectively according to the different inflammatory mediators.