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目的:观察十二指肠溃疡及肝硬化患者胃肠粘膜保护性激素——血浆生长抑素(SS)和前列腺素E_2(PGE_2)含量的变化。方法:用放免法检测正常人20例,十二指肠溃疡(Du)和肝硬化患者各20例血浆SS和PGE_2含量。结果:血浆SS正常人为(39.5±9.3)μg/L,Du组为(24.1±4.4)μg/L,肝硬化患者为(20.3±7.6)μg/L。血浆PGE_2正常人为(2617±344)μg/L,Du组为(2102±507)μg/L,肝硬化患者为(1308±273)μg/L,Du及肝硬化病人血浆SS和PGE_2含量比正常人降低(均P<0.01)。结论:Du和肝硬化患者血浆SS和PGE_2含量均减少,后者比前者减少更显著,这可能是Du和肝硬化门脉高压性胃肠病发病的重要因素之一。
Objective: To observe the changes of protective hormones - somatostatin (SS) and prostaglandin E_2 (PGE_2) in gastrointestinal mucosa of patients with duodenal ulcer and cirrhosis. Methods: The levels of plasma SS and PGE_2 in 20 patients with normal duodenal ulcer (Du) and cirrhosis were detected by radioimmunoassay. Results: The normal plasma level of SS was (39.5 ± 9.3) μg / L, that of Du (24.1 ± 4.4) μg / L for Du, and (20.3 ± 7.6) μg / L for cirrhosis. The plasma levels of PGE_2 in normal people were (2617 ± 344) μg / L, in Du patients (2102 ± 507) μg / L and in cirrhotic patients were (1308 ± 273) μg / L, respectively. People decreased (all P <0.01). Conclusions: The plasma levels of SS and PGE 2 in patients with Du and cirrhosis decreased, while the latter decreased more significantly than those in the former. This may be one of the important factors in the pathogenesis of portal hypertensive gastroenteritis in Du and cirrhosis.