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脉丝平 ( maspin)为丝氨酸蛋白酶抑制剂家族中独特的一员 ,这种分泌蛋白由 型肿瘤抑制基因编码 ,此基因的下调与乳腺癌和前列腺癌的发展有关。试验所用的是大肠杆菌产生的重组于谷胱甘肽 S-转移酶 ( GST)融合蛋白中的脉丝平。这种重组脉丝平剂量依赖性地阻断由血管内皮生长因
Maspin, a unique family of serine protease inhibitors, is encoded by a type-based tumor suppressor gene that is down-regulated in the development of breast and prostate cancer. The test used Escherichia coli produced recombinant verapamil in Glutathione S-transferase (GST) fusion protein. This recombinant verapamil dose-dependently blocks vascular endothelial growth factor