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目的探讨乙肝免疫球蛋白(HBIG)预防乙型肝炎病毒(HBV)母婴传播的效果。方法将146例无症状HBsAg(+)孕妇随机分为两组,两组孕妇所产婴儿,除常规接种乙肝疫苗外,均于出生后24h内和2周肌肉注射HBIG,然后随访并测定婴儿HBsAg和抗HBs。结果两组孕妇所生新生儿共检出HBsAg阳性20例,其中16例为双阳性母亲所生,提示HBIG对单纯HBsAg阳性孕妇宫内感染的阻断效果优于HBsAg、HBeAg双阳性孕妇。结论HBIG能有效预防母婴传播,降低HBV感染率。
Objective To investigate the effect of hepatitis B immunoglobulin (HBIG) on the prevention of hepatitis B virus (HBV) maternal-to-infant transmission. Methods 146 pregnant women with asymptomatic HBsAg (+) were randomly divided into two groups. The infants born to pregnant women in both groups were intramuscularly injected with HBIG intramuscularly within 24 h and 2 weeks after birth except for conventional hepatitis B vaccine. The HBsAg And anti-HBs. Results 20 cases of HBsAg positive neonates were detected in two groups of pregnant women, of which 16 cases were born by double-positive mothers, suggesting that the effect of HBIG in blocking intrauterine infection of HBsAg-positive pregnant women was better than that of HBsAg and HBeAg-positive pregnant women. Conclusion HBIG can effectively prevent mother-to-child transmission and reduce the HBV infection rate.