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研究表明,胰岛素抵抗(insulin resistance,IR)是糖尿病、肥胖症、高血压病和动脉粥样硬化等内分泌代谢性疾病的共同危险因素。血清增食欲素A(orexin A)是由下丘脑组织中合成并分泌的一种神经肽,通过其受体调节摄食、应激等多种生理过程,在肥胖、糖尿病发生中起重要作用。为研究增食欲素A在胰岛素抵抗及肥胖病理状态中的生物效应,本研究于2009年1-12月选取单纯营养肥胖型患者,检测并分析其血清增食欲素A水平与脂代谢相关性指标,探讨增食欲素A与胰岛素抵抗发生的相关性及其临床意义。现将结果
Studies have shown that insulin resistance (IR) is a common risk factor for endocrine and metabolic diseases such as diabetes, obesity, hypertension and atherosclerosis. Serum orexin A is a kind of neuropeptide synthesized and secreted by hypothalamus tissue. It plays an important role in the pathogenesis of obesity and diabetes by regulating its receptors such as feeding, stress and other physiological processes. In order to study the biological effect of orexin-A in the pathological state of insulin resistance and obesity, we selected the patients with simple obesity and obesity from January to December in 2009 to detect and analyze the serum levels of orexin-A and lipid metabolism , To explore the relationship between orexin A and insulin resistance and its clinical significance. Now the result