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在冠状动脉粥样硬化性心脏病(以下简称冠心病)发病机制的研究中,多数作者认为血脂代谢紊乱是重要发病因素之一。近年来,许多作者强调血清甘油三酯升高对冠心病发病的意义Gordon氏综合了一些学者的意见后提出,动脉粥样硬化不一定直接与血清胆固醇或β脂蛋白中的胆固醇含量有关,而与乳糜微粒中的胆固醇含量、乳糜微粒的大小和密度以及中性脂肪(即甘油三酯)有关。Albrink氏认为甘油三酯升高是冠心病患者最普遍的脂质异常,并且指出在临床上甘油三酯测定提供了冠心病患者与正常人之间最好的区别。最近Carlson等氏经九年随访的前向研究也表明,空腹血清甘油三酯浓度升高是冠心病的危险因素之一。其意义至少不小于胆固醇。国内游氏、
In the study of the pathogenesis of coronary atherosclerotic heart disease (hereinafter referred to as coronary heart disease), most authors believe that dyslipidemia is one of the important pathogenesis. In recent years, many authors have emphasized the significance of elevated serum triglycerides in the pathogenesis of coronary heart disease. Gordon’s synthesis of the opinions of some scholars suggested that atherosclerosis may not be directly related to the cholesterol content in serum cholesterol or beta lipoprotein, Cholesterol content in chylomicron, chylomicron size and density, and neutral fats (ie, triglycerides). Albrink’s view that elevated triglycerides is the most common lipid abnormality in patients with coronary heart disease, and pointed out that in clinical trials of triglycerides provide the best difference between patients with coronary heart disease and normal. Recent Carlson et al.’s nine-year follow-up of previous studies also showed that elevated fasting serum triglycerides is one of the risk factors for coronary heart disease. Its significance at least not less than cholesterol. Domestic travel,