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自身免疫性胰腺炎(AIP)是一种慢性胰腺炎,实验室检查、组织学检查、临床表现均显示与自身免疫有关。此病的特点为球蛋白、IgG4升高,抗Ⅱ碳酸酐酶抗体和抗乳铁蛋白抗体阳性,弥散性肿大的胰腺、显著的淋巴细胞浸润伴随纤维化。临床表现多样,经典的腹部CT表现为胰腺弥散性肿大呈腊肠样,密度均匀,轻微强化,周边低密度囊状缘,对糖皮质激素治疗敏感。该文就AIP目前的诊断及治疗进展作一综述。
Autoimmune pancreatitis (AIP) is a chronic pancreatitis, laboratory tests, histological examination, clinical manifestations are shown to be associated with autoimmunity. The disease is characterized by globulin, elevated IgG4, anti-carbonic anhydrase antibody and anti-lactoferrin antibody positive, diffusely enlarged pancreas, significant lymphocytic infiltration with fibrosis. Clinical manifestations of various classic abdominal CT showed diffuse swelling was sausage-like, uniform density, a slight enhancement, the surrounding low-density cystic margin, sensitive to glucocorticoid treatment. This article reviews the current diagnosis and treatment progress of AIP.