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目的 研究瘤净片治疗子宫肌瘤的作用机制。方法 采用雌激素、孕激素共同肌注的方法建立子宫肌瘤大鼠模型 ,采用放射免疫法检测血清性激素水平 ,ELISA法检测血清白介素 2 (IL 2 )、肿瘤坏死因子 α(TNF α)水平。结果 模型组大鼠雌、孕激素与TNF α水平较正常对照组相比均明显升高 ,IL 2降低。瘤净片组大鼠血清雌激素与模型组相比显著降低 ,IL 2水平较模型组明显升高。结论 子宫肌瘤的发生发展与内分泌紊乱、免疫功能低下有关。瘤净片通过调整内分泌、提高免疫功能 ,从而抑制肌瘤的生长。
Objective To study the mechanism of treatment of uterine fibroids by Tuomanetu. Methods A rat model of uterine fibroids was established by intramuscular injection of estrogen and progesterone. Serum sex hormone levels were detected by radioimmunoassay and serum interleukin 2 (IL 2) and tumor necrosis factor α (TNF α) levels were detected by ELISA. Results Compared with the normal control group, the levels of estrogen, progesterone and TNF α in the model group were significantly higher than those in the normal control group, and IL 2 was decreased. Compared with the model group, the serum estrogen level in the tumor group was significantly lower than that in the model group, and IL 2 levels were significantly higher than those in the model group. Conclusion The occurrence and development of uterine fibroids are related to endocrine disorders and low immune function. The tumor neoplasm inhibits the growth of fibroids by regulating endocrine and enhancing immune function.