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本文以三种实验性心律失常动物模型研究了陕西所产的苦参Sophora flaveacens Ait.根中提取的苦参碱和氧化苦参碱抗心律失常的作用,以及治疗心律失常的药理基础。Ⅰ、实验动物模型一、对大鼠由鸟头碱诱发心律失常的影响:给大鼠静注0.04—0.05毫克/公斤乌头碱,3—5分钟即出现心律失常,心律失常持续2—4小时。对照组10只,诱发多种类型的心律失常。苦参碱组10只,按LD_(50)的量0.1631/4克/公斤股静脉给药,5.34±1.0分,消除异位节律;氧化苦参碱组10只,按LD_(50)的1/4量0.12克/公斤,静脉给药8.50±0.65分,开始恢复窦性心律,给药组与对照组相差非常显著(P<0.01)。二、对抗由氯仿——肾上腺素引起心律失
In this paper, the effects of matrine and oxymatrine extracted from the roots of Sophora flaveacens Ait. from Shaanxi Province on the anti-arrhythmic effects of Sophora flaveacens Ait. and the pharmacological basis for the treatment of arrhythmia were studied in three experimental arrhythmia animal models. I. Experimental Animal Model I. Effect on arrhythmia induced by totoutou in rats: 0.0-4 to 0.05 mg/kg aconitine was given intravenously to rats, arrhythmia occurred within 3 to 5 minutes, and arrhythmia lasted 2-4 hour. Ten rats in the control group induced multiple types of arrhythmias. In the matrine group, 10 were dosed with 0.1631/4 g/kg LD_(50) in femoral vein, 5.34±1.0 points to eliminate ectopic rhythm; 10 were in oxymatrine group, and 1 was LD_(50). The amount of /4 was 0.12 g/kg, intravenous administration was 8.50±0.65 minutes, and sinus rhythm began to be restored. The difference between the administration group and the control group was very significant (P<0.01). Second, against heart failure caused by chloroform - adrenaline