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目的:评价复方胞二磷胆碱对视神经损害的治疗修复作用。方法:分别测定各组成年大鼠实验前后闪光视觉诱发电位(FVEP)和图形视觉诱发电位(PVEP)。结果:复方胞二磷胆碱组的FVEP和PVEP的潜伏期比空白对照组有显著缩短或极显著的缩短(P<0.05或P<0.01),比妥拉苏林组亦有显著缩短(P<0.05),复方胞二磷胆碱组比对照组也有显著缩短(P<0.05),而妥拉苏林组比对照组仅某些波有明显缩短。另外,不同药物剂量比较实验显示存在一定的量效关系。并随给药时间的延长而更为明显。结论:复方胞二磷胆碱对视神经有良好的恢复治疗作用,其作用远较妥拉苏林明显
Objective: To evaluate the therapeutic effect of compound citicoline on optic nerve damage. Methods: The flash visual evoked potentials (FVEP) and visual evoked potentials (PVEP) were measured before and after the experiment. Results: The latency of FVEP and PVEP in compound citicoline group was significantly shorter or significantly shorter than that in blank control group (P <0.05 or P <0.01) and also significantly shorter than that in tosufarin group (P < 0.05), the compound citicoline group also significantly shorter than the control group (P <0.05), and only some waves than the control group of tolazuline significantly shortened. In addition, different drug dose comparison experiments show that there is a certain dose-effect relationship. And with the extension of medication time and more obvious. Conclusion: Compound citicoline has a good therapeutic effect on the optic nerve, and its effect is much better than that of tolazulin