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目的探讨肿瘤坏死因子－α（ＴＮＦ－α）和降钙素基因相关肽（ＣＧＲＰ）在新生儿缺氧缺血性脑病（ＨＩＥ）中的变化及临床意义。方法采用放射免疫分析法对３８例ＨＩＥ患儿和１８例健康足月新生儿血浆ＴＮＦ－α与ＣＧＲＰ水平进行了同期动态观察。结果ＨＩＥ患儿急性期ＴＮＦ—α，ＣＧＲＰ水平分别为（１．１２±０．４２）ｎｇ／ｍｌ，（８８．９２±２３．１６）ｎｇ／ｍｌ；恢复期分别为（０．６１±０ ．１８）ｎｇ／ｍｌ，（６８．３９±１９．３２）ｎｇ／ｍｌ；对照组分别为（０．５４±０．１５）ｎｇ／ｍｌ，（６６． ２± １４．５４） ｎｇ／ｍｌ。急性期血浆 ＴＮＦ－ α和 ＣＧＲＰ水平较恢复期显著增高（ Ｐ＜ ０． ０１），并明显高于同期对照组水平（ Ｐ ＜０．０１），恢复期与正常对照组无显著差异，急性期不同程度 ＨＩＥ与对照组 ＴＮＦ— α，ＣＧＲＰ水平比较，重度ＨＩＥ组ＴＮＦ—α，ＣＧＲＰ分别为（１．２８±０． ４１）ｎｇ／ｍｌ，（１１８．１２ ± ３０．２５）ｎｇ／ｍｌ；中度ＨＩＥ组分别为（０．９５±０．３）ｎｇ／ｍｌ，（８６．４９±２４．３６）ｎｇ／ｍｌ，轻度ＨＩＥ组分别为（０．６３±０．１９）ｎｇ／ｍｌ，（６８．３±１８．３８）ｎｇ／ｍｌ，?
Objective To investigate the changes and clinical significance of tumor necrosis factor-α (TNF-α) and calcitonin gene related peptide (CGRP) in neonatal hypoxic-ischemic encephalopathy (HIE) Methods The levels of plasma TNF-α and CGRP in 38 HIE infants and 18 healthy term neonates were observed by radioimmunoassay in the same period. Results The levels of TNF-α and CGRP in acute stage of HIE children were (1.12 ± 0.42) ng / ml and (88.92 ± 23.16) ng / ml, respectively. The recovering time was (0.61 ± 0) .18) ng / ml and (68.39 ± 19.32) ng / ml, respectively. The control group was (0.54 ± 0.15) ng / ml and (66.2 ± 14.54) ng / ml respectively. The levels of TNF-α and CGRP in acute phase were significantly higher than those in recovery phase (P <0.01), and were significantly higher than those in control group (P <0.01). There was no significant difference between recovery phase and normal control group. The levels of TNF-α and CGRP in severe HIE group were (1.28 ± 0.41) ng / ml and (118.12 ± 30.25) ng / ml, respectively, with different degrees of HIE and control group; The moderate HIE group was (0.95 ± 0.3) ng / ml and (86.49 ± 24.36) ng / ml respectively, while the mild HIE group was (0.63 ± 0.19) ng / ml , (68.3 ± 18.38) ng / ml ,?