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目的观察慢性病毒性肝炎、肝硬化及肝硬化合并自发性细菌性腹膜炎患者血清白介素－８（ＩＬ－８）的变化，探讨其与肝细胞损伤及感染的关系。方法采用ＥＩＩＳＡ法检测２５例慢性病毒性肝炎，３０例肝硬化及１５例肝硬化合并自发性细菌性腹膜炎患者血清ＩＬ－８的变化。常规方法检测慢性肝病患者谷丙转氨酶（ＡＬＴ）的变化。结果慢性病毒性肝炎及肝硬化患者血清ＩＬ－８均明显高于正常对照组（Ｐ＜０．００１和Ｐ＜０．０１）。肝硬化合并自发性细菌性腹膜炎患者ＩＬ－８分别高于慢性病毒性肝炎（Ｐ＜０．０５）和肝硬化无自发性腹膜炎者（Ｐ＜０．０１）。慢性肝病患者血清ＩＬ－８水平与ＡＬＴ呈正相关（ｒ＝０．６１，Ｐ＜０．０５）。结论ＩＬ－８可能参与了慢性肝病时肝细胞的免疫损伤，但ＩＬ－８与感染的关系更为密切。
Objective To observe the changes of serum interleukin-8 (IL-8) in patients with chronic viral hepatitis, cirrhosis and cirrhosis complicated with spontaneous bacterial peritonitis and to explore its relationship with hepatocellular injury and infection. Methods The changes of serum IL-8 in 25 patients with chronic viral hepatitis, 30 patients with cirrhosis and 15 patients with cirrhosis complicated with spontaneous bacterial peritonitis were detected by EIISA. Routine method for detection of alanine aminotransferase (ALT) changes in patients with chronic liver disease. Results The levels of IL-8 in patients with chronic viral hepatitis and cirrhosis were significantly higher than those in normal controls (P <0.001 and P <0.01). Patients with cirrhosis and spontaneous bacterial peritonitis had higher levels of IL-8 than those with chronic viral hepatitis (P <0.05) and those with cirrhosis without spontaneous peritonitis (P <0.01). Serum IL-8 levels in patients with chronic liver disease were positively correlated with ALT (r = 0.61, P <0.05). Conclusion IL-8 may be involved in the immune damage of hepatocytes in chronic liver disease, but IL-8 is more closely related to infection.