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目的:探讨血清IL-6及S-100B水平变化对颅脑损伤患者病情程度及预后评估的临床价值。方法:选择我院2013年7月~2015年7月收治的颅脑损伤患者100例为研究对象,依据格拉斯哥昏迷评分(GCS)将患者分为特重型损伤组、重型损伤组、中型损伤组和轻型损伤组,每组25例。另选择同期在我院接受体检的25位健康志愿者作为对照组。采用酶联免疫吸附法检测各组研究对象不同时间点血清IL-6及S-100B水平,并分析IL-6及S-100B水平变化与颅脑损伤程度及预后的关系。结果:颅脑损伤后第1、3、5、7、14天患者血清IL-6及S-100B水平均显著高于对照组,差异具有统计学意义(P<0.05)。在相同检测时间,损伤程度越重的患者其血清IL-6及S-100B水平越高,差异具有统计学意义(P<0.05);相同损伤程度颅脑损伤患者随着损伤时间延长,其血清IL-6水平越高,差异具有统计学意义(P<0.05);相同损伤程度颅脑损伤患者血清S-100B水平在损伤后第1天开始上升,第3天达到高峰,第5天开始下降,差异具有统计学意义(P<0.05)。颅脑损伤患者血清IL-6和S-100B水平与格拉斯哥预后评分(GOS)和格拉斯哥昏迷评分(GCS)呈负相关(rIL-6=-0.812、-0.770,rS-100B=-0.767、-0.831,P<0.05),与颅脑损伤程度呈正相关关系(r=0.776、0.791,P<0.05)。结论:血清IL-6和S-100B水平与颅脑损伤患者病情严重程度和预后相关,对颅脑损伤程度的临床诊断及预后评估具有重要参考价值。
Objective: To investigate the clinical value of serum IL-6 and S-100B levels in assessing the severity and prognosis of patients with craniocerebral injury. Methods: One hundred patients with craniocerebral injury who were treated in our hospital from July 2013 to July 2015 were selected as the research object. According to Glasgow Coma Scale (GCS), the patients were divided into special heavy injury group, severe injury group, medium injury group and Light injury group, 25 cases in each group. Another select the same period in our hospital for medical examination of 25 healthy volunteers as a control group. Serum levels of IL-6 and S-100B at different time points were detected by enzyme-linked immunosorbent assay. The relationship between the levels of IL-6 and S-100B and the degree and prognosis of brain injury were analyzed. Results: The levels of IL-6 and S-100B in the serum of patients on the 1st, 3rd, 5th, 7th and 14th day after craniocerebral injury were significantly higher than those of the control group (P <0.05). The serum IL-6 and S-100B levels of patients with more severe injury at the same test time were significantly higher (P <0.05); with the same degree of injury, Serum levels of S-100B increased with the increase of IL-6 level in the same injury group (P <0.05). The level of S-100B in the traumatic brain injury group increased from the first day after injury to the highest level on the third day, , The difference was statistically significant (P <0.05). Serum levels of IL-6 and S-100B in patients with craniocerebral injury were negatively correlated with Glasgow Outcomes Scale and Glasgow Coma Scale (GCS) (rIL-6 = -0.812, -0.770, rS-100B = -0.767, -0.831 , P <0.05), and had a positive correlation with the degree of brain injury (r = 0.776,0.791, P <0.05). Conclusion: Serum levels of IL-6 and S-100B correlate with the severity and prognosis of patients with craniocerebral injury, which is of important value in the clinical diagnosis and prognosis evaluation of brain injury.