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目的 :探讨鼻NK/T细胞淋巴瘤 (NK/T celllymphoma )的临床特征、组织病理学特点、治疗效果和预后 ,为诊断和治疗提供经验。方法 :对 9例鼻NK/T细胞淋巴瘤患者均取活组织标本进行组织病理学检查及形态学和免疫表型分析 ;按AnnArbor国际分期标准进行临床分期。 9例分别采用单纯放疗 (1例 )、单纯化疗 (2例 )、局部放疗结合全身联合化疗 (6例 )等治疗方法。结果 :9例鼻NK/T细胞淋巴瘤局部病变均表现为黏膜弥漫性浸润、溃疡 ,组织坏死脱落 ,而非结节状外生性肿物 ;组织病理学特征为NK/T细胞淋巴瘤有血管中心、血管浸润和坏死现象 ,细胞呈多型性 ;免疫组化特点为CD4 5RO+,CD4 3+,CD3ε+,CD5 6 +。 9例患者全部死亡 ,从发病至死亡时间为 3～34个月。结论 :鼻NK/T细胞淋巴瘤多原发于下鼻甲和鼻中隔 ,好发于男性 ,病程短、病情进展快、恶性度较高 ,具有独特的免疫学和病理学特点 ,具有较高的侵袭性 ,预后差
Objective: To investigate the clinical features, histopathological features, therapeutic effects and prognosis of nasal NK / T cell lymphoma and provide experience for diagnosis and treatment. Methods: Nine cases of nasal NK / T-cell lymphoma patients were biopsied for histopathological examination and morphological and immunophenotypic analysis; according to AnnArbor international staging standards for clinical staging. Nine cases were treated with radiotherapy alone (1 case), chemotherapy alone (2 cases), local radiotherapy combined with systemic chemotherapy (6 cases) and other treatment methods. Results: All the 9 cases of nasal NK / T cell lymphoma showed diffuse infiltration, ulceration and necrosis of the mucous membrane, but not nodular exogenous tumor. The histopathological features of the NK / T cell lymphoma were blood vessel Center, vascular infiltration and necrosis phenomenon, the cells were polymorphic; immunohistochemical characteristics of CD4 5RO +, CD4 3 +, CD3ε +, CD5 6 +. All 9 patients died from onset to death for 3 to 34 months. CONCLUSIONS: Nasal NK / T-cell lymphoma mostly occurs in the inferior turbinate and nasal septum and occurs predominantly in men with short course, rapid progression and high malignancy. It has unique immunological and pathological features with high invasion Sexual, poor prognosis