目的探讨高浓度促卵泡生成素(FSH)、促黄体生成素(LH)、促甲状腺激素(TSH)对测定人绒毛膜促性腺激素(β-HCG)浓度的影响。方法收集2014年5月-10月在本院体检的人群,选取FSH、LH、TSH正常的健康女性98例为正常对照组;选取FSH>38 IU/L及LH>12 IU/L者101例为高FSH、LH组;选取TSH>5.2 m IU/L及FSH与LH正常的年轻女性42例为女性高TSH组;选取TSH>5.2 m IU/L健康体检的年轻男性54例为男性高TSH组,分别检测各组的β-HCG浓度,并对各组β-HCG进行统计学分析。结果高FSH、LH组和高TSH组的β-HCG浓度高于正常对照组,高FSH、LH组高于高TSH组,差异均有统计学意义(P<0.05)。男性高TSH组血清β-HCG浓度高于女性高TSH组,差异有统计学意义(P<0.05)。结论部分正常绝经期妇女高浓度的FSH、LH会伴随β-HCG不同程度升高;女性TSH对β-HCG值呈现正干扰但影响程度有限;部分男性高浓度TSH会引起β-HCG浓度假性升高,不同实验室对绝经期妇女和男性应该建立相应的参考范围,为临床诊治提供可靠依据。 Objective To investigate the effects of high concentrations of follicle stimulating hormone (FSH), luteinizing hormone (LH) and thyrotropin (TSH) on the determination of human chorionic gonadotropin (β-HCG) concentration. Methods A total of 98 healthy women with normal FSH, LH and TSH were selected as the normal control group from May to October in 2014. 101 healthy women with FSH> 38 IU / L and LH> 12 IU / L were enrolled in this study. 42 cases of young female with TSH> 5.2 m IU / L and normal FSH and LH were female high TSH group; 54 young men with TSH> 5.2 m IU / L healthy physical examination were male high TSH Group, the concentration of β-HCG in each group was detected, and the β-HCG in each group was statistically analyzed. Results The concentration of β-HCG in high FSH group, LH group and high TSH group were higher than those in normal control group, high FSH group and LH group were higher than those in high TSH group (P <0.05). The serum concentration of β-HCG in men with high TSH was higher than that in women with high TSH, the difference was statistically significant (P <0.05). CONCLUSIONS: High concentrations of FSH and LH in some normal postmenopausal women increase with varying degrees of β-HCG. Female TSH exhibit positive interference with limited positive effects on the value of β-HCG. Some men with high concentrations of TSH may cause pseudo-HCG concentration Rise in different laboratories for menopausal women and men should establish the corresponding reference range, provide a reliable basis for clinical diagnosis and treatment.