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[目的]比较注射用紫杉醇脂质体(力扑素)与传统紫杉醇注射液治疗卵巢癌的疗效及毒副反应。[方法]2004年6月至2007年12月卵巢癌患者100例,分为试验组和对照组。试验组(50例)给紫杉醇脂质体(力扑素)每次剂量135mg/m2;对照组(50例)给紫杉醇每次剂量135mg/m2。两组均联合卡铂化疗,每3周重复1次为1个周期,共6个周期。[结果]试验组完全缓解18例,部分缓解19例,总有效率74%;对照组完全缓解15例,部分缓解21例,总有效率72%,两组疗效差异无统计学意义。在血压和血液学毒性方面,两组发生率差异无统计学意义。在非血液学毒性方面,恶心、呕吐、皮疹、肌肉痛的发生率,试验组明显低于对照组,差异有统计学意义。[结论]紫杉醇脂质体(力扑素)与传统紫杉醇对卵巢癌治疗的效果相当,皮疹和肌肉痛等过敏反应,紫杉醇脂质体明显低于紫杉醇注射液。
[Objective] To compare the efficacy and side effects of paclitaxel injection liposomal injection with traditional paclitaxel injection in the treatment of ovarian cancer. [Method] 100 patients with ovarian cancer from June 2004 to December 2007 were divided into experimental group and control group. The experimental group (50 cases) gave paclitaxel liposomes (force pleurins) each dose of 135mg / m2; the control group (50 cases) paclitaxel each dose of 135mg / m2. Both groups were combined carboplatin chemotherapy, repeated once every 3 weeks for a cycle, a total of 6 cycles. [Results] In the experimental group, 18 cases were completely relieved, 19 cases partially relieved, and the total effective rate was 74%. In the control group, 15 cases were completely relieved and 21 cases were partially relieved. The total effective rate was 72%. There was no significant difference between the two groups. In terms of blood pressure and hematologic toxicity, there was no significant difference in incidence between the two groups. In non-hematological toxicity, the incidence of nausea, vomiting, rash and muscle pain was significantly lower in the experimental group than in the control group, with statistically significant differences. [Conclusion] paclitaxel liposomes (force pleurins) and traditional paclitaxel on ovarian cancer treatment effect, rash and muscle pain and other allergic reactions, paclitaxel liposomes was significantly lower than paclitaxel injection.