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The flame temperature in the combustor of a gas turbine is usually as high as 2000K, while the maximum temperature that can be endured by metal materials is less than 1200K at present. Therefore, various protective and cooling measures are needed to ensure the operation life of the liner wall which wraps the flame. The lean premixed combustor can meet the increasingly stringent emission requirements, but it requires more air for premixed combustion and then less air for cooling and dilution. In order to obtain a better impingement jet cooling structure, this paper studied the impingement jet cooling structure with vertical circular holes of equal diameter under single outlet condition. The structural variables studied include the jet hole diameter D, the impinging distance Z, the jet hole length (jet plate thickness) t, and the jet-to-jet spacing X is ignored. Among them, X/D (the ratio of the jet-to-jet spacing to the jet diameter) is inversely correlated with the mass flow rate. Within the constant X/D being equal to 10, the influence of D, Z and t on the average heat transfer coefficient h of the target surface under same mass flow was determined by means of conjugate numerical heat transfer analysis and orthogonal test. The results show that Z has significant influence on h, D has moderate influence on h, and t has negligible influence on h. Further, by means of regression orthogonal test, the influence trend of parameters Z and D on h at X/D=10 was studied. The optimal values of Z and D within the research scope were found.