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目的 观察葛根素、弥可保联合治疗糖尿病周围神经病变的疗效。方法 90例 (男 4 9例 ,女 4 1例 ) 2型糖尿病周围神经病变 ,随机分为两组 ,治疗组 4 8例应用葛根素 0 3g ,加入生理盐水 2 5 0ml,或木糖醇5 0 0ml中静滴 ,1次 /d ;弥可保 5 0 0 μg ,肌注 ,1次 /d。对照组 4 2例用维生素B110 0mg ,肌注 ,1次 /d ;维生素B12 5 0 0 μg ,1次 /d。两组均以 15d为 1个疗程。 结果 治疗组总有效率 89 6 % ,对照组为 6 4 3% ,两组比较差异有显著意义 (P <0 0 1)。药物不良反应轻微。结论 在严格控制血糖、血脂、血压的基础上 ,联合应用葛根素、弥可保治疗糖尿病周围神经病变有较好的疗效 ,能减少糖尿病的致残率。
Objective To observe the curative effect of puerarin and methycobal on diabetic peripheral neuropathy. Methods Totally 90 patients (49 males and 41 females) with peripheral neuropathy of type 2 diabetes were randomly divided into two groups. In the treatment group, 48 cases received puerarin 0 3 g and added 250 ml normal saline or xylitol 5 0 0ml intravenous infusion, 1 / d; miconazole 500 μg, intramuscular injection, 1 time / d. The control group 42 cases with vitamin B110mg, intramuscular injection, 1 / d; vitamin B12 500 g, 1 / d. Both groups were 15d for a course of treatment. Results The total effective rate was 89.6% in the treatment group and 64.3% in the control group, with significant difference between the two groups (P <0.01). Minor adverse drug reactions. Conclusion On the basis of strict control of blood glucose, blood lipids and blood pressure, the combination of puerarin and methycobal can effectively treat diabetic peripheral neuropathy and reduce the morbidity of diabetes mellitus.