1例67岁男性脑梗死患者因合并抑郁状态给予帕罗西汀20 mg,1次/d口服。5 d后患者出现乏力、情感淡漠、食欲减退。实验室检查:血钠128 mmol/L(服用帕罗西汀前为136 mmol/L)。停用帕罗西汀,改服氟哌噻吨美利曲辛,并给予氯化钠口服。1周后血钠升至134 mmol/L,淡漠及乏力感减轻。1个月后复查,血钠142 mmol/L。 A 67-year-old man with cerebral infarction was given Paroxetine 20 mg orally once daily due to depression. 5 days after the patient fatigue, indifference, loss of appetite. Laboratory tests: Serum sodium 128 mmol / L (before taking paroxetine 136 mmol / L). Paroxetine was discontinued, flupirtipine was substituted for melitracen, and sodium chloride was given orally. After 1 week, serum sodium rose to 134 mmol / L, indifference and fatigue reduced. After 1 month review, serum sodium 142 mmol / L.