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非O1/O139群霍乱弧菌引起的腹泻在许多发展中国家都有发生,其流行涉及到多个血清群。在有些地方,非O1/O139群霍乱弧菌腹泻的发病率甚至超过了O1/O139群霍乱弧菌腹泻的发病率。非O1/O139群霍乱弧菌的致病因子多种多样,肠毒素、蛋白酶、溶血素和三型分泌系统等被认为是重要的致病因子,但其致病机制非常复杂,至今仍然不完全清楚。随着抗生素使用的增加,出现了许多耐药甚至多重耐药菌株。本研究从非O1/O139群霍乱弧菌腹泻的流行情况、致病因子以及耐药方面加以综述。
Diarrhea caused by non-O1 / O139 Vibrio cholerae occurs in many developing countries and its prevalence involves multiple serogroups. In some places, the incidence of Vibrio cholera non-O1 / O139 diarrhea even exceeds the incidence of Vibrio cholerae O1 / O139 diarrhea. Non-O1 / O139 Vibrio cholerae have a variety of pathogenic factors, and enterotoxins, proteases, hemolysins and type III secretion systems are considered as important virulence factors, but their pathogenesis is very complicated and still not complete clear. With the increasing use of antibiotics, many resistant and even multi-drug resistant strains have emerged. This review summarizes the prevalence, virulence factors and drug resistance of non-O1 / O139 Vibrio cholerae diarrhea.