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本文用考马斯亮蓝法和ＥＬＩＳＡ双抗体夹心法，检测了３０例正常健康人和６９例消化道恶性肿瘤治疗前后血清ＡＳＰ和ＣＥＡ值的动态变化。治疗前明显高于正常对照（Ｐ＜０．０１）。３４例癌症手术切除后，ＡＳＰ和ＣＥＡ值降低，复发、转移时，再次升高。但在应激状态（手术、炎症、创伤、等）时，血清ＡＳＰ值暂时升高，二周后下降接近正常；治疗前ＡＳＰ和ＣＥＡ值升高，治疗后无变化或继续升高的有效率不如前两者（Ｐ＜０．０１）；ＡＳＰ和ＣＥＡ阳性者治疗效果较阴性者差。病变有复发、伴远处转移者较无复发、无远处转移者阳性率高；ＡＳＰ和ＣＥＡ阴性有效率为９２．８６％和９６．５５％；阳性者仅有５３．８５％和６０．０％，两者相比有显著性差异（Ｐ＜０．０１）。结果显示动态观察血清ＡＳＰ和ＣＥＡ值，对判断消化道恶性肿瘤疗效、复发、病程转归和预后有重要价值。
In this study, the dynamic changes of serum ASP and CEA before and after treatment of 30 patients with normal healthy and 69 patients with digestive tract malignancy were detected by Coomassie brilliant blue method and ELISA double antibody sandwich method. Before treatment was significantly higher than the normal control (P <0.01). After surgical resection of 34 cases of cancer, the values of ASP and CEA decreased, and recurrence and metastasis increased again. However, in the stress state (surgery, inflammation, trauma, etc.), the serum ASP level temporarily rises, and falls to near normal after two weeks; the ASP and CEA values increase before treatment, and there is no change or continue to increase after treatment. Not as good as the first two (P<0.01); ASP and CEA positive patients were worse than negative ones. The positive rate of recurrence, distant metastasis, no recurrence, no distant metastasis was high; the negative rate of ASP and CEA was 92.86% and 96.55%; the positive rate was only 53.85% and 60. 0%, there was a significant difference between the two (P<0.01). The results showed that the dynamic observation of serum ASP and CEA values was of great value in judging the efficacy, recurrence, course of disease, and prognosis of gastrointestinal cancer.