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比较环丙沙星或氧氟沙星联用抗结核药的肝毒性。分别测定异烟肼组、利福平组、异烟肼利福平联合用药组及分别联用氧氟沙星或环丙沙星组小鼠的血清谷氨酸氨基转移酶、肝指数、肝匀浆丙二醛含量、肝微粒体细胞色素 P4 50、线粒体 Ca2 +ATP酶活性及肝病理检查。结果表明异烟肼和利福平联用氧氟沙星或环丙沙星肝毒性均不比异烟肼和利福平联合时强
To compare the hepatotoxicity of ciprofloxacin or ofloxacin with anti-TB drugs. The levels of serum glutamate aminotransferase, liver index and liver in the isoniazid, rifampin, isoniazid and rifampicin combined groups and the mice inloxacin or ciprofloxacin groups were measured respectively The content of malondialdehyde, cytochrome P450 of liver microsome, Ca2 + ATPase activity of mitochondria and liver pathological examination were measured. The results show that both isoniazid and rifampicin combined with ofloxacin or ciprofloxacin hepatotoxicity than isoniazid and rifampin when combined